KPV

Summary

KPV is being researched for its role in gut health, systemic inflammation, and skin barrier function. Technically, it is the C-terminal tripeptide of the α-MSH hormone (positions 11-13); it is one of the most studied anti-inflammatory peptides, especially in the gut and skin, and also retains some of the antimicrobial activity of the α-MSH from which it is derived.

What is it researched for?

• •  Intestinal inflammation
• •  Skin inflammation and skin barrier
• •  Systemic inflammation
• •  Antimicrobial activity

Cycle and break

Mechanism of action

Inflammation modulation (NF-κB)

It is transported into the cell by the PepT1 system, stabilizes the IκBα protein, and limits the nuclear translocation of the p65 subunit of NF-κB, reducing the transcription of TNF-α, IL-1β, IL-6, IL-8, and MCP-1.

Gut-brain and skin axis

It also modulates MAPK cascades (ERK1/2, JNK, p38) and is being investigated in skin inflammation and neuroimmune communication of the gut-brain axis.

Scientific evidence

Intestinal inflammation: studied in colitis models (DSS and TNBS) with reduction of intestinal inflammation.

Skin inflammation: preclinical models support its local anti-inflammatory action.

Product use

KPV is a prominent reference material in research on intestinal and skin inflammation. At Peptido BioGenetic, we offer it as a high-purity peptide for laboratory use, with a certificate of analysis (COA) available upon request.

⚠️ Product intended exclusively for research and laboratory use. Not suitable for human or veterinary consumption.