MOTS C

Summary

MOTS-c is studied as a metabolic regulator: it improves physical endurance, insulin sensitivity, and the conversion of fat to energy. Technically, it is a 16-amino acid mitochondrial peptide, encoded by mitochondrial DNA itself and discovered in 2015, which is considered an "exercise mimetic" due to its ability to improve metabolic efficiency.

What is it researched for?

• •  Metabolic efficiency and physical endurance
• •  Insulin sensitivity and glucose metabolism
• •  Conversion of fat to energy
• •  Metabolic aging and neuroprotection

Cycle and break

Mechanism of action

AMPK activation and metabolism

It activates the AMPK pathway, the cell's master energy sensor, and regulates purine and glucose metabolism, promoting mitochondrial efficiency.

Mitochondria-nucleus communication

It is one of the few peptides that translocates from the mitochondria to the nucleus to directly modulate gene expression in response to metabolic stress.

Aging and neuroprotection

It is being investigated in metabolic disorders, age-related conditions, and neurodegenerative diseases.

Scientific evidence

Metabolism: Studies describe improved insulin sensitivity and glucose metabolism, replicating exercise effects.

Nuclear translocation: Its nuclear translocation under cellular stress has been documented since its discovery (Lee et al., 2015).

Longevity and neuroprotection: Preclinical models support effects on metabolic longevity and neuroprotection.

Product use

As a mitochondria-derived peptide with exercise mimetic action, MOTS-c is a unique reference material in metabolism and aging research. At Peptido BioGenetic, we offer it as a high-purity peptide, with a certificate of analysis (COA) available upon request.

⚠️ Product intended exclusively for research and laboratory use. Not suitable for human or veterinary consumption.