5 AMINO 1MQ

Summary

5-Amino-1MQ is being studied for its role in energy metabolism and NAD⁺ biology: it regulates adipocyte lipid metabolism and mitochondrial efficiency. Technically, it is a small molecule inhibitor of the enzyme NNMT (nicotinamide N-methyltransferase), a metabolic target of great interest in aging and obesity research due to its role in NAD⁺ availability.

What is it being researched for?

• •  NNMT inhibition and NAD⁺ rescue
• •  Adipocyte lipid metabolism
• •  Mitochondrial efficiency and energy expenditure
• •  NAD⁺/SIRT1 signaling and metabolic homeostasis

Cycle and break

Mechanism of action

NNMT inhibition and NAD⁺ rescue

By blocking NNMT, it spares nicotinamide and promotes NAD⁺ regeneration, the central cofactor for energy metabolism and sirtuins (SIRT1).

Adipocyte metabolism

Its ability to reprogram the lipid metabolism of fat cells towards increased energy consumption is being investigated.

Mitochondrial efficiency

Its effect on mitochondrial function and metabolic homeostasis is being studied through NAD⁺/SIRT1 signaling.

Scientific evidence

Adipocytes: Studies in adipocytes show that NNMT inhibition reduces fat accumulation and improves cellular energy expenditure.

Fat mass: Preclinical models describe a reduction in fat mass without affecting intake.

Metabolic synergy: Investigated alongside NAD⁺ modulators for its metabolic synergy.

Product use

5-Amino-1MQ is a prominent reference material in energy metabolism and NAD⁺ biology research. At Peptido BioGenetic, we offer it for research grade, with a certificate of analysis (COA) available upon request.

⚠️ Product intended exclusively for research and laboratory use. Not suitable for human or veterinary consumption.