IGF-1 LR3

Summary

IGF-1 LR3 (Long R3 IGF-1) is the long-acting variant of insulin-like growth factor 1, studied for its role in muscle hyperplasia, recovery, and nutrient transport. Technically, it is an 83-amino acid analog with an arginine substitution at position 3 and a 13-residue peptide extension at the N-terminal end, which drastically reduces its binding to transport proteins (IGFBPs), prolonging its half-life and biological activity compared to native IGF-1.

What is it researched for?

• •  Hyperplasia and muscle tissue growth
• •  Anabolic signaling via IGF-1R
• •  Transport of amino acids and glucose into cells
• •  Muscle tissue recovery

Cycle and rest

Mechanism of action

IGF-1R Receptor Agonism

It activates the IGF-1 receptor (IGF-1R) and triggers the PI3K/Akt/mTOR and MAPK/ERK pathways, central routes for protein synthesis, proliferation, and cell survival.

Prolonged half-life due to low affinity for IGFBP

The N-terminal extension and the Arg3 substitution reduce its capture by circulating IGFBPs, so a larger fraction remains free and active, multiplying its potency compared to recombinant IGF-1.

Hyperplasia and nutrient uptake

It is investigated for its role in hyperplasia (proliferation of new cells), the transport of amino acids and glucose into cells, and muscle tissue recovery.

Scientific evidence

IGF-1R Signaling: receptor studies describe potent anabolic signaling through the PI3K/Akt pathway, which is the basis of its effect on cell growth.

Biological Potency: in vitro models, Long R3 IGF-1 shows several times higher biological potency than native IGF-1 due to its reduced sequestration by IGFBP.

Muscle Tissue: preclinical data associate IGF-1 signaling with myoblast proliferation and muscle tissue growth.

Product use

Due to its prolonged half-life and potent signaling through IGF-1R, IGF-1 LR3 is a prominent reference material in growth factor, hypertrophy, and cellular hyperplasia research. At Peptido BioGenetic, we supply it as a high-purity peptide for laboratory use, with a Certificate of Analysis (COA) available upon request.

⚠️ Product intended exclusively for research and laboratory use. Not suitable for human or veterinary consumption.