TB 500
Summary
TB-500 is being investigated for its role in connective tissue repair, flexibility, and muscle recovery. Technically, it is the synthetic active fraction of thymosin beta-4 (Tβ4), a naturally occurring 43-amino acid peptide that acts as the primary regulator of actin, the most abundant protein in the cytoskeleton.
What is it researched for?
- • Connective and musculoskeletal tissue repair
- • Cell migration to the injury site
- • Angiogenesis and inflammation resolution
- • Functional recovery after tissue damage
Cycle and Rest
Mechanism of Action
Tissue Repair and Cell Migration
It sequesters G-actin monomers and controls F-actin polymerization, a mechanism that directs cell migration, proliferation, and differentiation to the injury site and accelerates tissue remodeling.
Angiogenesis and Resolution of Inflammation
It stimulates endothelial cell proliferation and the formation of new blood vessels, and modulates the NF-κB pathway, promoting an anti-inflammatory and resolution environment.
Neuroprotection and Functional Recovery
It has been studied in models of stroke and nervous system injury, where it promotes axonal remodeling and improves functional recovery.
Scientific Evidence
Tissue Repair: Tβ4 has advanced to human clinical trials (RegeneRx) for dermal wound healing, corneal ulcers, and cardiac repair after infarction, demonstrating accelerated migration of keratinocytes and endothelial cells.
Angiogenesis: preclinical models of cardiac and dermal damage show increased angiogenesis and reduced fibrosis.
Neuroprotection: studies in rodents describe neurological improvement and remodeling after ischemic damage.
Product Use
With a unique mechanism of action on the cytoskeleton and backing in clinical trials of Tβ4, TB-500 is a benchmark in regeneration and healing research. At Peptido BioGenetic, we select it as a high-purity peptide for laboratory use, with a certificate of analysis (COA) available upon request.
⚠️ Product intended exclusively for research and laboratory use. Not for human or veterinary consumption.
Garantía de Pureza >98.5% Analizado independientemente por espectroscopia y pruebas HPLC. Empaque térmico priority incluido en el envío.
Información Clínica
Especificaciones Técnicas
- Compuesto TB-500 / Timosina Beta-4 (Tβ4)
- Número CAS 77591-33-4
- Fórmula Molecular C212H350N56O78S
- Peso Molecular 4963,5 g/mol
- Contenido 10 mg por vial
- Presentación Polvo liofilizado (vial)
- Pureza Verificada según estándares de laboratorio europeos · COA disponible bajo solicitud
