{"product_id":"kisspeptin-10-5-mg","title":"KISSPEPTIN 10","description":"\u003cp style=\"font-size:.8em;letter-spacing:.12em;text-transform:uppercase;color:#9ca3af;font-weight:600;margin:0 0 .4em;font-family:inherit;\"\u003eSummary\u003c\/p\u003e\n\u003cp style=\"font-size:1.05em;line-height:1.65;margin:0 0 1.2em;\"\u003e\u003cstrong\u003eKisspeptin-10\u003c\/strong\u003e is one of the reference peptides in the \u003cstrong\u003eendocrine and reproductive\u003c\/strong\u003e field: it is being researched for its role in the \u003cstrong\u003enatural production of sex hormones and the balance of the reproductive axis\u003c\/strong\u003e. Technically, it is the 10-amino acid C-terminal fragment of kisspeptin (product of the KISS1 gene, also called metastin), an agonist of the KISS1R receptor (GPR54) and one of the master regulators located upstream of GnRH in the hypothalamic-pituitary-gonadal axis.\u003c\/p\u003e\n\n\u003cp style=\"font-size:.8em;letter-spacing:.12em;text-transform:uppercase;color:#9ca3af;font-weight:600;margin:1.9em 0 .6em;font-family:inherit;\"\u003eWhat is it researched for?\u003c\/p\u003e\n\u003cul style=\"margin:0 0 1.2em;padding-left:0;list-style:none;line-height:1.9;\"\u003e\n\n  \u003cli style=\"padding-left:1.3em;text-indent:-1.3em;margin:0;\"\u003e\n\n\u003cspan style=\"color:#0099ff;font-weight:700;\"\u003e•\u003c\/span\u003e  Regulation of the reproductive and endocrine axis\u003c\/li\u003e\n\n  \u003cli style=\"padding-left:1.3em;text-indent:-1.3em;margin:0;\"\u003e\n\n\u003cspan style=\"color:#0099ff;font-weight:700;\"\u003e•\u003c\/span\u003e  Secretion of gonadotropins (LH and FSH)\u003c\/li\u003e\n\n  \u003cli style=\"padding-left:1.3em;text-indent:-1.3em;margin:0;\"\u003e\n\n\u003cspan style=\"color:#0099ff;font-weight:700;\"\u003e•\u003c\/span\u003e  Fertility, puberty, and gonadal function\u003c\/li\u003e\n\n  \u003cli style=\"padding-left:1.3em;text-indent:-1.3em;margin:0;\"\u003e\n\n\u003cspan style=\"color:#0099ff;font-weight:700;\"\u003e•\u003c\/span\u003e  Interaction between metabolic status and reproduction\u003c\/li\u003e\n\n\n\u003c\/ul\u003e\n\n\u003cp style=\"font-size:.8em;letter-spacing:.12em;text-transform:uppercase;color:#9ca3af;font-weight:600;margin:1.9em 0 .6em;font-family:inherit;\"\u003eCycle and break\u003c\/p\u003e\n\u003cdiv style=\"display:flex;gap:12px;margin:0 0 1.4em;flex-wrap:wrap;\"\u003e\n\n  \u003cdiv style=\"flex:1;min-width:150px;padding:12px 16px;background:#f6f6f7;border-radius:10px;\"\u003e\n\n    \u003cdiv style=\"font-size:.72em;text-transform:uppercase;letter-spacing:.08em;color:#9ca3af;margin-bottom:2px;\"\u003eCycle\u003c\/div\u003e\n\n    \u003cdiv style=\"font-weight:600;\"\u003e4–6 weeks\u003c\/div\u003e\n\n  \u003c\/div\u003e\n\n  \u003cdiv style=\"flex:1;min-width:150px;padding:12px 16px;background:#f6f6f7;border-radius:10px;\"\u003e\n\n    \u003cdiv style=\"font-size:.72em;text-transform:uppercase;letter-spacing:.08em;color:#9ca3af;margin-bottom:2px;\"\u003eBreak\u003c\/div\u003e\n\n    \u003cdiv style=\"font-weight:600;\"\u003e2–4 weeks\u003c\/div\u003e\n\n  \u003c\/div\u003e\n\n\n\u003c\/div\u003e\n\n\u003cp style=\"font-size:.8em;letter-spacing:.12em;text-transform:uppercase;color:#9ca3af;font-weight:600;margin:1.9em 0 .6em;font-family:inherit;\"\u003eMechanism of action\u003c\/p\u003e\n\u003cp style=\"margin:1.1em 0 0.3em;font-weight:600;font-family:inherit;\"\u003eRegulation of the reproductive axis (GnRH stimulation)\u003c\/p\u003e\n\u003cp style=\"margin:0 0 0.9em;line-height:1.6;\"\u003eStimulates hypothalamic GnRH neurons, triggering the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary, the initial step in the reproductive cascade.\u003c\/p\u003e\n\u003cp style=\"margin:1.1em 0 0.3em;font-weight:600;font-family:inherit;\"\u003eSignaling via KISS1R receptor (GPR54)\u003c\/p\u003e\n\u003cp style=\"margin:0 0 0.9em;line-height:1.6;\"\u003eBinds to the G protein-coupled receptor KISS1R (GPR54), activating the Gq\/11-phospholipase C pathway, with mobilization of intracellular calcium and activation of the MAPK cascade.\u003c\/p\u003e\n\u003cp style=\"margin:1.1em 0 0.3em;font-weight:600;font-family:inherit;\"\u003eResearch in reproduction and metabolism\u003c\/p\u003e\n\u003cp style=\"margin:0 0 0.9em;line-height:1.6;\"\u003eIt is being researched in the context of fertility, puberty, gonadal function, and the interaction between metabolic status and reproduction.\u003c\/p\u003e\n\n\u003cp style=\"font-size:.8em;letter-spacing:.12em;text-transform:uppercase;color:#9ca3af;font-weight:600;margin:1.9em 0 .6em;font-family:inherit;\"\u003eScientific evidence\u003c\/p\u003e\n\u003cp style=\"margin:0 0 0.7em;padding:10px 14px;background:#f3f4f6;border-radius:8px;font-size:.92em;color:#4b5563;line-height:1.5;\"\u003e\u003cstrong\u003eLH secretion:\u003c\/strong\u003e In human studies, kisspeptin administration robustly induces LH secretion (Dhillo et al.), confirming its role as an activator of the gonadotropic axis.\u003c\/p\u003e\n\u003cp style=\"margin:0 0 0.7em;padding:10px 14px;background:#f3f4f6;border-radius:8px;font-size:.92em;color:#4b5563;line-height:1.5;\"\u003e\u003cstrong\u003eGPR54 receptor:\u003c\/strong\u003e Loss of GPR54 function is associated with hypogonadotropic hypogonadism, establishing kisspeptin as an essential regulator of puberty and fertility.\u003c\/p\u003e\n\u003cp style=\"margin:0 0 0.7em;padding:10px 14px;background:#f3f4f6;border-radius:8px;font-size:.92em;color:#4b5563;line-height:1.5;\"\u003e\u003cstrong\u003eClinical application:\u003c\/strong\u003e Clinical programs are exploring kisspeptin as a tool to physiologically modulate gonadotropin secretion.\u003c\/p\u003e\n\n\u003cp style=\"font-size:.8em;letter-spacing:.12em;text-transform:uppercase;color:#9ca3af;font-weight:600;margin:1.9em 0 .6em;font-family:inherit;\"\u003eProduct use\u003c\/p\u003e\n\u003cp style=\"margin:0 0 0.9em;line-height:1.6;\"\u003eAs a master regulator located upstream of GnRH, Kisspeptin-10 is a unique reference material in reproductive endocrinology research and the hypothalamic-pituitary-gonadal axis. At \u003cstrong\u003ePeptido BioGenetic\u003c\/strong\u003e, we supply it as a high-purity peptide for laboratory use, with a certificate of analysis (COA) available upon request.\u003c\/p\u003e\n\n\u003cp style=\"margin:1.6em 0 0;padding:12px 14px;background:#f3f4f6;border-radius:8px;font-size:.92em;color:#4b5563;line-height:1.5;\"\u003e⚠️ Product intended exclusively for \u003cstrong\u003eresearch and laboratory use\u003c\/strong\u003e. Not suitable for human or veterinary consumption.\u003c\/p\u003e","brand":"PeptidoBioGenetic","offers":[{"title":"10 mg","offer_id":54548710326601,"sku":"KS10","price":132.0,"currency_code":"EUR","in_stock":false},{"title":"80 mg","offer_id":54760619114825,"sku":"KS80","price":198.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1016\/7507\/3865\/files\/kisspeptin-10-5-mg-sin-fondo.png?v=1782819768","url":"https:\/\/www.peptidobiogenetic.com\/en\/products\/kisspeptin-10-5-mg","provider":"PeptidoBioGenetic","version":"1.0","type":"link"}