{"product_id":"dsip-5-mg","title":"DSIP","description":"\u003cp style=\"font-size:.8em;letter-spacing:.12em;text-transform:uppercase;color:#9ca3af;font-weight:600;margin:0 0 .4em;font-family:inherit;\"\u003eSummary\u003c\/p\u003e\n\u003cp style=\"font-size:1.05em;line-height:1.65;margin:0 0 1.2em;\"\u003e\u003cstrong\u003eDSIP\u003c\/strong\u003e is one of the reference neuropeptides in the field of \u003cstrong\u003esleep, circadian rhythm, and stress\u003c\/strong\u003e: it is researched for its direct relationship with \u003cstrong\u003edeep sleep architecture\u003c\/strong\u003e. Technically, it is a natural nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) isolated in 1977 from the cerebral blood of sleeping rabbits.\u003c\/p\u003e\n\n\u003cp style=\"font-size:.8em;letter-spacing:.12em;text-transform:uppercase;color:#9ca3af;font-weight:600;margin:1.9em 0 .6em;font-family:inherit;\"\u003eWhat is it researched for?\u003c\/p\u003e\n\u003cul style=\"margin:0 0 1.2em;padding-left:0;list-style:none;line-height:1.9;\"\u003e\n\n  \u003cli style=\"padding-left:1.3em;text-indent:-1.3em;margin:0;\"\u003e\n\n\u003cspan style=\"color:#0099ff;font-weight:700;\"\u003e•\u003c\/span\u003e  Deep delta wave sleep\u003c\/li\u003e\n\n  \u003cli style=\"padding-left:1.3em;text-indent:-1.3em;margin:0;\"\u003e\n\n\u003cspan style=\"color:#0099ff;font-weight:700;\"\u003e•\u003c\/span\u003e  Circadian rhythm and sleep-wake cycle\u003c\/li\u003e\n\n  \u003cli style=\"padding-left:1.3em;text-indent:-1.3em;margin:0;\"\u003e\n\n\u003cspan style=\"color:#0099ff;font-weight:700;\"\u003e•\u003c\/span\u003e  Stress response and neuroendocrine axis\u003c\/li\u003e\n\n  \u003cli style=\"padding-left:1.3em;text-indent:-1.3em;margin:0;\"\u003e\n\n\u003cspan style=\"color:#0099ff;font-weight:700;\"\u003e•\u003c\/span\u003e  Central antioxidant defense\u003c\/li\u003e\n\n\n\u003c\/ul\u003e\n\n\u003cp style=\"font-size:.8em;letter-spacing:.12em;text-transform:uppercase;color:#9ca3af;font-weight:600;margin:1.9em 0 .6em;font-family:inherit;\"\u003eCycle and Rest\u003c\/p\u003e\n\u003cdiv style=\"display:flex;gap:12px;margin:0 0 1.4em;flex-wrap:wrap;\"\u003e\n\n  \u003cdiv style=\"flex:1;min-width:150px;padding:12px 16px;background:#f6f6f7;border-radius:10px;\"\u003e\n\n    \u003cdiv style=\"font-size:.72em;text-transform:uppercase;letter-spacing:.08em;color:#9ca3af;margin-bottom:2px;\"\u003eCycle\u003c\/div\u003e\n\n    \u003cdiv style=\"font-weight:600;\"\u003eIntermittent nighttime use\u003c\/div\u003e\n\n  \u003c\/div\u003e\n\n  \u003cdiv style=\"flex:1;min-width:150px;padding:12px 16px;background:#f6f6f7;border-radius:10px;\"\u003e\n\n    \u003cdiv style=\"font-size:.72em;text-transform:uppercase;letter-spacing:.08em;color:#9ca3af;margin-bottom:2px;\"\u003eRest\u003c\/div\u003e\n\n    \u003cdiv style=\"font-weight:600;\"\u003eNot required\u003c\/div\u003e\n\n  \u003c\/div\u003e\n\n\n\u003c\/div\u003e\n\n\u003cp style=\"font-size:.8em;letter-spacing:.12em;text-transform:uppercase;color:#9ca3af;font-weight:600;margin:1.9em 0 .6em;font-family:inherit;\"\u003eMechanism of action\u003c\/p\u003e\n\u003cp style=\"margin:1.1em 0 0.3em;font-weight:600;font-family:inherit;\"\u003eDeep sleep and circadian rhythm\u003c\/p\u003e\n\u003cp style=\"margin:0 0 0.9em;line-height:1.6;\"\u003eIts name comes from its ability to promote delta wave sleep. It modulates glutamatergic signaling and GABAergic neurotransmission, key to the brain's excitation-inhibition balance.\u003c\/p\u003e\n\u003cp style=\"margin:1.1em 0 0.3em;font-weight:600;font-family:inherit;\"\u003eNeuroendocrine axis and stress\u003c\/p\u003e\n\u003cp style=\"margin:0 0 0.9em;line-height:1.6;\"\u003eIt influences neuroendocrine pathways (CRF, ACTH, GnRH, LH, TSH, and GH axis) and monoaminergic systems (dopamine, serotonin, noradrenaline, histamine), with an anti-stress profile.\u003c\/p\u003e\n\u003cp style=\"margin:1.1em 0 0.3em;font-weight:600;font-family:inherit;\"\u003eAntioxidant defense and blood-brain barrier\u003c\/p\u003e\n\u003cp style=\"margin:0 0 0.9em;line-height:1.6;\"\u003eIt increases the activity of antioxidant enzymes (GPx, SOD, catalase, glutathione reductase) and crosses the blood-brain barrier via transporters, facilitating its central action.\u003c\/p\u003e\n\n\u003cp style=\"font-size:.8em;letter-spacing:.12em;text-transform:uppercase;color:#9ca3af;font-weight:600;margin:1.9em 0 .6em;font-family:inherit;\"\u003eScientific Evidence\u003c\/p\u003e\n\u003cp style=\"margin:0 0 0.7em;padding:10px 14px;background:#f3f4f6;border-radius:8px;font-size:.92em;color:#4b5563;line-height:1.5;\"\u003e\u003cstrong\u003eBrain distribution:\u003c\/strong\u003e Detected in the thalamus, cortex, cerebellum, hypothalamus, and brainstem, with fluctuations throughout the sleep-wake cycle.\u003c\/p\u003e\n\u003cp style=\"margin:0 0 0.7em;padding:10px 14px;background:#f3f4f6;border-radius:8px;font-size:.92em;color:#4b5563;line-height:1.5;\"\u003e\u003cstrong\u003eStress and hormones:\u003c\/strong\u003e Studies describe modulation of stress response and hormone release.\u003c\/p\u003e\n\u003cp style=\"margin:0 0 0.7em;padding:10px 14px;background:#f3f4f6;border-radius:8px;font-size:.92em;color:#4b5563;line-height:1.5;\"\u003e\u003cstrong\u003eAntioxidation:\u003c\/strong\u003e Cellular models confirm its antioxidant activity.\u003c\/p\u003e\n\n\u003cp style=\"font-size:.8em;letter-spacing:.12em;text-transform:uppercase;color:#9ca3af;font-weight:600;margin:1.9em 0 .6em;font-family:inherit;\"\u003eProduct Use\u003c\/p\u003e\n\u003cp style=\"margin:0 0 0.9em;line-height:1.6;\"\u003eDue to its direct link with delta sleep and its neuroendocrine profile, DSIP is a unique reference material in sleep, circadian rhythm, and stress research. At \u003cstrong\u003ePeptido BioGenetic\u003c\/strong\u003e, we offer it as a high-purity peptide for laboratory use, with a Certificate of Analysis (COA) available upon request.\u003c\/p\u003e\n\n\u003cp style=\"margin:1.6em 0 0;padding:12px 14px;background:#f3f4f6;border-radius:8px;font-size:.92em;color:#4b5563;line-height:1.5;\"\u003e⚠️ Product intended exclusively for \u003cstrong\u003eresearch and laboratory use\u003c\/strong\u003e. Not suitable for human or veterinary consumption.\u003c\/p\u003e","brand":"PeptidoBioGenetic","offers":[{"title":"10 mg","offer_id":54545811767625,"sku":"DS10","price":110.0,"currency_code":"EUR","in_stock":false},{"title":"15 mg","offer_id":55126423109961,"sku":"DS15","price":132.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1016\/7507\/3865\/files\/dsip-5-mg-sin-fondo.png?v=1782819725","url":"https:\/\/www.peptidobiogenetic.com\/en\/products\/dsip-5-mg","provider":"PeptidoBioGenetic","version":"1.0","type":"link"}