{"product_id":"ghk-cu-50-mg","title":"GHK Cu","description":"\u003cp style=\"font-size:.8em;letter-spacing:.12em;text-transform:uppercase;color:#9ca3af;font-weight:600;margin:0 0 .4em;font-family:inherit;\"\u003eSummary\u003c\/p\u003e\n\u003cp style=\"font-size:1.05em;line-height:1.65;margin:0 0 1.2em;\"\u003e\u003cstrong\u003eGHK-Cu\u003c\/strong\u003e is investigated for its role in \u003cstrong\u003ecollagen and elastin, wound healing, and skin firmness and health\u003c\/strong\u003e. Technically, it is the copper(II) complex of the tripeptide glycyl-L-histidyl-L-lysine, an endogenous molecule naturally present in human plasma, saliva, and urine, which transports copper into the cell and acts as a regenerative modulator, antioxidant, and anti-inflammatory even at nanomolar concentrations. It is probably the most studied copper peptide in regenerative biology.\u003c\/p\u003e\n\n\u003cp style=\"font-size:.8em;letter-spacing:.12em;text-transform:uppercase;color:#9ca3af;font-weight:600;margin:1.9em 0 .6em;font-family:inherit;\"\u003eWhat is it investigated for?\u003c\/p\u003e\n\u003cul style=\"margin:0 0 1.2em;padding-left:0;list-style:none;line-height:1.9;\"\u003e\n\n  \u003cli style=\"padding-left:1.3em;text-indent:-1.3em;margin:0;\"\u003e\n\n\u003cspan style=\"color:#0099ff;font-weight:700;\"\u003e•\u003c\/span\u003e  Collagen and elastin synthesis\u003c\/li\u003e\n\n  \u003cli style=\"padding-left:1.3em;text-indent:-1.3em;margin:0;\"\u003e\n\n\u003cspan style=\"color:#0099ff;font-weight:700;\"\u003e•\u003c\/span\u003e  Skin healing and firmness\u003c\/li\u003e\n\n  \u003cli style=\"padding-left:1.3em;text-indent:-1.3em;margin:0;\"\u003e\n\n\u003cspan style=\"color:#0099ff;font-weight:700;\"\u003e•\u003c\/span\u003e  Antioxidant and anti-inflammatory defense\u003c\/li\u003e\n\n  \u003cli style=\"padding-left:1.3em;text-indent:-1.3em;margin:0;\"\u003e\n\n\u003cspan style=\"color:#0099ff;font-weight:700;\"\u003e•\u003c\/span\u003e  Angiogenesis and extracellular matrix remodeling\u003c\/li\u003e\n\n  \u003cli style=\"padding-left:1.3em;text-indent:-1.3em;margin:0;\"\u003e\n\n\u003cspan style=\"color:#0099ff;font-weight:700;\"\u003e•\u003c\/span\u003e  Epigenetic regulation of gene expression\u003c\/li\u003e\n\n\n\u003c\/ul\u003e\n\n\u003cp style=\"font-size:.8em;letter-spacing:.12em;text-transform:uppercase;color:#9ca3af;font-weight:600;margin:1.9em 0 .6em;font-family:inherit;\"\u003eCycle \u0026amp; Break\u003c\/p\u003e\n\u003cdiv style=\"display:flex;gap:12px;margin:0 0 1.4em;flex-wrap:wrap;\"\u003e\n\n  \u003cdiv style=\"flex:1;min-width:150px;padding:12px 16px;background:#f6f6f7;border-radius:10px;\"\u003e\n\n    \u003cdiv style=\"font-size:.72em;text-transform:uppercase;letter-spacing:.08em;color:#9ca3af;margin-bottom:2px;\"\u003eCycle\u003c\/div\u003e\n\n    \u003cdiv style=\"font-weight:600;\"\u003e4–6 weeks\u003c\/div\u003e\n\n  \u003c\/div\u003e\n\n  \u003cdiv style=\"flex:1;min-width:150px;padding:12px 16px;background:#f6f6f7;border-radius:10px;\"\u003e\n\n    \u003cdiv style=\"font-size:.72em;text-transform:uppercase;letter-spacing:.08em;color:#9ca3af;margin-bottom:2px;\"\u003eBreak\u003c\/div\u003e\n\n    \u003cdiv style=\"font-weight:600;\"\u003e4 weeks\u003c\/div\u003e\n\n  \u003c\/div\u003e\n\n\n\u003c\/div\u003e\n\n\u003cp style=\"font-size:.8em;letter-spacing:.12em;text-transform:uppercase;color:#9ca3af;font-weight:600;margin:1.9em 0 .6em;font-family:inherit;\"\u003eMechanism of Action\u003c\/p\u003e\n\u003cp style=\"margin:1.1em 0 0.3em;font-weight:600;font-family:inherit;\"\u003eExtracellular Matrix Regeneration and Collagen Synthesis\u003c\/p\u003e\n\u003cp style=\"margin:0 0 0.9em;line-height:1.6;\"\u003eGHK-Cu activates dermal fibroblasts—the connective tissue cells that produce the extracellular matrix (ECM)—and drives its remodeling. Through the TGF-β signaling pathway, it upregulates type I collagen, elastin, and glycosaminoglycan expression while adjusting the balance between metalloproteinases (MMP1, MMP2) and their tissue inhibitors (TIMP1, TIMP2) to prevent excessive tissue degradation. In wound healing models, collagen synthesis increases by \u003cstrong\u003e70% to 230%\u003c\/strong\u003e, reaching up to nine times in in vitro assays with fibroblasts.\u003c\/p\u003e\n\u003cp style=\"margin:1.1em 0 0.3em;font-weight:600;font-family:inherit;\"\u003eAntioxidant and Anti-inflammatory Action\u003c\/p\u003e\n\u003cp style=\"margin:0 0 0.9em;line-height:1.6;\"\u003eIt provides bioavailable copper to the enzyme Cu,Zn-SOD1, mimicking superoxide dismutase activity and reducing reactive oxygen species (ROS) such as superoxide and hydroxyl radicals. Additionally, it limits iron release from ferritin (up to 87% inhibition), decreases lipid peroxidation byproducts, and protects against LDL oxidation. On the anti-inflammatory front, it suppresses NF-κB (p65) and p38 MAPK pathways, leading to a reduction in mediators such as TNF-α, IL-6, and fibrinogen.\u003c\/p\u003e\n\u003cp style=\"margin:1.1em 0 0.3em;font-weight:600;font-family:inherit;\"\u003eStimulation of Angiogenesis\u003c\/p\u003e\n\u003cp style=\"margin:0 0 0.9em;line-height:1.6;\"\u003eIt promotes the formation of new blood vessels by increasing VEGF and bFGF (FGF2) secretion by fibroblasts and mesenchymal stem cells. Released from the SPARC protein during tissue injury, it promotes endothelial proliferation in early repair phases and moderates it in later phases.\u003c\/p\u003e\n\u003cp style=\"margin:1.1em 0 0.3em;font-weight:600;font-family:inherit;\"\u003eEpigenetic Modulation of Gene Expression\u003c\/p\u003e\n\u003cp style=\"margin:0 0 0.9em;line-height:1.6;\"\u003eGHK-Cu modifies the expression of more than \u003cstrong\u003e1,000 genes\u003c\/strong\u003e—approximately 1,569 upregulated and 583 downregulated—acting as an epigenetic regulator by inhibiting histone deacetylases (HDACs). This reactivates regenerative pathways (TGF-β, integrins, p63) while attenuating gene programs associated with inflammation and tumor processes.\u003c\/p\u003e\n\n\u003cp style=\"font-size:.8em;letter-spacing:.12em;text-transform:uppercase;color:#9ca3af;font-weight:600;margin:1.9em 0 .6em;font-family:inherit;\"\u003eScientific Evidence\u003c\/p\u003e\n\u003cp style=\"margin:0 0 0.7em;padding:10px 14px;background:#f3f4f6;border-radius:8px;font-size:.92em;color:#4b5563;line-height:1.5;\"\u003e\u003cstrong\u003eCollagen and Matrix:\u003c\/strong\u003e In vitro studies in fibroblasts and rat wound models document collagen increases of up to 9×, with gene profiles confirming TGF-β pathway activation.\u003c\/p\u003e\n\u003cp style=\"margin:0 0 0.7em;padding:10px 14px;background:#f3f4f6;border-radius:8px;font-size:.92em;color:#4b5563;line-height:1.5;\"\u003e\u003cstrong\u003eAntioxidant and Anti-inflammatory:\u003c\/strong\u003e UV radiation protection assays in keratinocytes and fibroblast cultures show cytokine decreases; animal models confirm ROS neutralization.\u003c\/p\u003e\n\u003cp style=\"margin:0 0 0.7em;padding:10px 14px;background:#f3f4f6;border-radius:8px;font-size:.92em;color:#4b5563;line-height:1.5;\"\u003e\u003cstrong\u003eAngiogenesis:\u003c\/strong\u003e Gene data reflects a \u003cstrong\u003e487% increase in ANGPT1 expression\u003c\/strong\u003e; studies in rabbit wounds show greater granulation tissue and vascularization.\u003c\/p\u003e\n\u003cp style=\"margin:0 0 0.7em;padding:10px 14px;background:#f3f4f6;border-radius:8px;font-size:.92em;color:#4b5563;line-height:1.5;\"\u003e\u003cstrong\u003eGene Regulation:\u003c\/strong\u003e Microarray analyses (e.g., Connectivity Map) show broad effects; in COPD models, the reversal of 127 genes towards a healthier profile has been described.\u003c\/p\u003e\n\n\u003cp style=\"font-size:.8em;letter-spacing:.12em;text-transform:uppercase;color:#9ca3af;font-weight:600;margin:1.9em 0 .6em;font-family:inherit;\"\u003eProduct Use\u003c\/p\u003e\n\u003cp style=\"margin:0 0 0.9em;line-height:1.6;\"\u003eDue to this comprehensive profile, GHK-Cu is a key peptide in research lines on tissue regeneration and wound healing, extracellular matrix and collagen biology, antioxidant defense, and hair follicle signaling. At \u003cstrong\u003ePeptido BioGenetic\u003c\/strong\u003e, we supply it as high-purity material for laboratory use, with a Certificate of Analysis (COA) available upon request.\u003c\/p\u003e\n\n\u003cp style=\"margin:1.6em 0 0;padding:12px 14px;background:#f3f4f6;border-radius:8px;font-size:.92em;color:#4b5563;line-height:1.5;\"\u003e⚠️ Product intended exclusively for \u003cstrong\u003eresearch and laboratory use\u003c\/strong\u003e. Not for human or veterinary consumption.\u003c\/p\u003e","brand":"PeptidoBioGenetic","offers":[{"title":"100 mg","offer_id":54603479712073,"sku":"CU100","price":158.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1016\/7507\/3865\/files\/ghk-cu-50-mg-sin-fondo.png?v=1782825071","url":"https:\/\/www.peptidobiogenetic.com\/en-us\/products\/ghk-cu-50-mg","provider":"PeptidoBioGenetic","version":"1.0","type":"link"}